Thursday, July 11, 2013

Remarks by the President in Presentation of the 2012 Medals of Arts and the Medals of Humanities

The White House

Office of the Press Secretary

For Immediate Release

July 10, 2013

East Room

2:16 P.M. EDT
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THE PRESIDENT:? Thank you so much.? (Applause.)? Thank you. (Applause.)? Hey!? Thank you.? Everybody, please have a seat.? See, everybody is cheering because I've bought their books, I've seen their movies, I buy their records.? (Laughter.)? So we're major contributors here.
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Well, hello, everybody, and welcome to the White House.? Thank you for joining us to celebrate the recipients of the 2012 -- because I guess this is retrospective -- National Medal of Arts and National Humanities Medals.
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One of the special privileges of this office is getting a chance to honor individuals who?ve played an important role in my life as well as in the nation?s life.? And that?s what today is all about -- celebrating some extraordinary men and women who?ve used their talents in the arts and the humanities to open up minds and nourish souls, and help us understand what it means to be human, and what it means to be an American.
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I want to give some special thanks to the people who help to preserve and to support that cultural legacy -- the Acting Chairwoman of the National Endowment for the Arts, Joan Shigekawa.? Give Joan a big round of applause.? (Applause.)? Where is she?? There she is.? And her predecessor, the irrepressible Rocco Landesman -- (applause) -- as well as the Acting Chairwoman of the National Endowment for the Humanities, Carole Watson.? (Applause.)? Both organizations do an incredible job lifting up some of today?s best artists and scholars, and helping to cultivate the next generation of talent and intellect.
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And I?d like to also acknowledge the co-chairs of the President?s Committee on the Arts and Humanities, George Stevens, Jr. -- where?s George?? There he is.? (Applause.)? As well as Margo Lion -- where?s Margo?? Good to see you.? (Applause.)? As well as members of Congress who are here today, all of whom support the arts.
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But we are primarily here to acknowledge these incredible individuals.? And, frankly, this is just fun for me because I feel like I know you all because I've enjoyed your performances; your writings have fundamentally changed me -- I think for the better, Marilynne.? I believe that.
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At first glance, this is a pretty diverse group.? We?ve got incredible singers and dancers; we have poets and producers; musicians, playwrights, scholars.?? They come from all across the country, all around the world.? And yet, for all their differences, today?s honorees have one thing in common -- and that is they are teachers.? Whether they realize it or not, they?ve taught us about ourselves and about our world.
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American philosopher Will Durant once wrote, ?The aim of art is to represent not the outward appearance of things, but their inward significance.?? And that's an extraordinary skill -- to tell the untold stories of history; to reveal the sculpture that's waiting there in a block of stone; to transform written music into song; to make it look like those planes in space are actually flying like they are.? (Laughter.)? I'm just saying, I remember when I first saw Star Wars.? (Laughter.)? There?s a whole generation that thinks special effects always look like they do today.? (Laughter.)? But it used to be you?d see, like, the string -- (laughter) -- on the little model spaceships.? Anyway, I'm being led astray.? (Laughter.)???
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Because the arts and the humanities aren?t just a source of entertainment, they challenge us to think and to question and to discover, to seek that inward significance -- and that helps us grow and to change and to reach new heights, and to understand each other at a time when the world is constantly crying for the capacity to bridge that gap and speak to people who aren't like us.
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And that?s exactly what these artists and these humanists have done -- by working hard, developing their craft, following their dreams, never giving up.?
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Somebody like Allen Toussaint, who is being honored here for his incredible contributions to the rhythm and blues and jazz music of his beloved New Orleans.? After his hometown was battered by Katrina and Allen was forced to evacuate, he did something even more important for his city -- he went back.? And since then, Allen has devoted his musical talent to lifting up and building up a city.? And today, he?s taking the stage all over the world, with all kinds of incredible talent, doing everything he can to revive the legendary soul of the Big Easy.
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Somebody like Ernest Gaines, who grew up as the descendent of sharecroppers in the South and farming the same land as his ancestors.? He did not let that define his future.? Instead, he took that experience and used it to help fill in gaps in American literature with the stories of African American life.? And then, Ernest moved back to Louisiana, onto the very same land he and his family had once worked.? And he spent more than 20 years teaching college students to find their own voices and reclaiming some of the stories of their own families and their own lives.
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Somebody like Joan Didion, who, rightly, has earned distinction as one of most celebrated American writers of her generation.? I?m surprised she hasn?t already gotten this award. (Laughter.)? But in her early years, she was in school only sporadically, basically taught herself how to read while she and her family followed her Army officer father around the country.? She obviously learned quickly.? She won a contest for Vogue in college; gave up her dream of being an oceanographer, writing became her world.? And today, decades into her career, she remains one of our sharpest and most respected observers of American politics and culture.
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What?s true for those three is true for all the recipients here.? So many of you have touched me and touched Michelle, and now we?re trying to get them to -- Malia and Sasha to see some of Anna?s work, or read ?The Iliad*? because we want to share that, because we think it was important to us.
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And we celebrate people like our honorees here today not just because of their talent, but because they create something new.? They create a new space and that becomes a lasting contribution to American life.? And that?s true for all of these honorees.
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So together, the men and women with us today have helped us appreciate individual talent, but as I said earlier, they?ve also helped us to bridge our differences -- to recognize all the things we share as Americans, whether it?s arts or humanities or sports.?
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Frank, I grew up reading Sports Illustrated, and I think it was very good for me.? I don't know about you.? (Laughter.)? Because all these endeavors, they don't discriminate, they don't prejudge -- they speak to all of us equally if we?re open to it. They?re part of all of our common heritage.? They convey all these distinct voices and emotions and stories, and that's us.? That's who we are.??
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So for more than 200 years that culture has helped shape our views of democracy and freedom and tolerance and progress.? Sometimes the observations or the incredible art or scholarship that?s been done by these honorees are overlooked, but somewhere they?re having an impact.? And like Bobby Kennedy talked about, they create ?ripples of hope.?? They?re like stones in a lake, and it emanates, and we never know exactly how, or who, will be touched by it.? But it makes a difference.? And it?s made us better.?
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And the work that we honor today, the lifetime achievement of these artists and these scholars, reminds us that the human imagination is still the most powerful tool that we have as a people.? That?s why we celebrate their creativity and the fundamental optimism, the notion that if they work that hard somebody will actually pay attention.? That?s why we have to remain committed to the dreamers and the creators and innovators who fuel that progress and help us light the way ahead, because our children, our grandchildren deserve to grow up in a country where their dreams know no bounds and their ambitions extend as far as their talents and hard work can take them.? And it?s important that they have examples -- people who?ve carved out a path for them.?
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So I want to thank today?s honorees for doing their part to foster that spirit, to enrich our entire nation.? Every one of them has helped us see beyond outward appearances and appreciate the significance of what?s within.? And for that we are incredibly grateful.
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So it is now my privilege to present these medals to each of them as one of our military aides reads their citations.? (Applause.)
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(The citations are read and the medals are awarded.)
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MILITARY AIDE:? National Medal of Arts recipients:?
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Herb Alpert.? (Applause.)? For his varied contributions to music and the fine arts.? The musician behind Tijuana Brass phenomenon and co-founder of A&M Records, which launched several storied careers, Mr. Alpert is also a philanthropist who shares the power of arts education with young people across our country. (Applause.)
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Lin Arison.? (Applause.)? For her contributions as a philanthropist and arts education advocate.? Co-founder of the National YoungArts Foundation and the New World Symphony, Ms. Arison?s work celebrates, showcases, and supports the next generation of great American artists.? (Applause.)
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Joan Myers Brown.? (Applause.)? For her contributions as a dancer, choreographer and artistic director.? Founder of the Philadelphia Dance Company, Ms. Brown carved out an artistic haven for African American dancers and choreographers to innovate, create, and share their unique visions with the national and global dance communities.? (Applause.)
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Ren?e Fleming.? (Applause.)? For her contributions to American music.? Known to many as ?the people?s diva,? Ms. Fleming has captivated audiences around the world with an adventurous repertoire spanning opera and the classical tradition to jazz and contemporary pop.? (Applause.)
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Ernest J. Gaines.? (Applause.)? For his contributions as an author and teacher.? Drawing deeply from his childhood in the rural South, his works have shed new light on the African American experience and given voice to those who have endured injustice.? (Applause.)
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Ellsworth Kelly.? (Applause.)? For his contributions as a painter, sculptor and printmaker.? A careful observer of form, color and the natural world, Mr. Kelly has shaped more than half a century of abstraction and remains a vital influence in American art.? (Applause.)
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Tony Kushner.? (Applause.)? For his contributions to American theater and film.? Whether for the stage or the silver screen, his scripts have moved audiences worldwide, marrying humor to fury, history to fantasy, and the philosophical to the personal.? (Applause.)
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George Lucas.? (Applause.)? For his contributions to American cinema.? By combining the art of storytelling with boundless imagination and cutting-edge techniques, Mr. Lucas has transported us to new worlds and created some of the most beloved and iconic films of all time.? (Applause.)
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Elaine May.? (Applause.)? For her contributions to American comedy.? With groundbreaking wit and a keen understanding of how humor can illuminate our lives, Ms. May has evoked untold joy, challenged expectations, and elevated spirits across our nation. (Applause.)
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Laurie Olin.? (Applause.)? For his contributions as a preeminent landscape architect.? Renowned for his acute sense of harmony and balance between nature and design, Mr. Olin has dedicated his energy to shaping many iconic spaces around the world and to educating new leaders in his art.? (Applause.)
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Allen Toussaint.? (Applause.)? For his contributions as a composer, producer and performer.? Born and raised in New Orleans, Mr. Toussaint has built a legendary career alongside America?s finest musicians, sustaining his city?s rich tradition of rhythm and blues, and lifting it to the national stage.? (Applause.)
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Accepting on behalf of Washington Performing Arts Society, Jenny Bellfield.? (Applause.)? For bringing world-class performances to our Nation?s Capital.? From concert hall premieres to in-school workshops, Washington Performing Arts Society has drawn renowned artists to the Washington community and inspired generations of young performers to follow their passions.? (Applause.)
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National Humanities Medal recipients:
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Edward L. Ayers.? (Applause.)? For his commitment to making our history as widely available and accessible as possible.? Dr. Ayers?s innovations in digital humanities extend higher learning beyond campus boundaries and allow broad audiences to discover the past in new ways.? (Applause.)
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Accepting on behalf of William G. Bowen, David Bowen.? (Applause.)? For his contributions to the study of economics and his probing research on higher education in America.? While his widely discussed publications have scrutinized the effects of policy, Dr. Bowen has used his leadership to put theories into practice and strive for new heights of academic excellence.
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Jill Ker Conway.? (Applause.)? For her contributions as a historian and trailblazing academic leader.? Dr. Conway has inspired generations of scholars, and her studies of exceptional and empowered women have revealed a common drive that unites women across the globe to create, to lead, and to excel.? (Applause.)
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Natalie Zemon Davis.? (Applause.)? For her insights into the study of history and her exacting eloquence in bringing the past into focus.? With vivid description and exhaustive research, her works allow us to experience life through our ancestors? eyes and to engage truly with our history.? (Applause.)
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Frank Deford.? (Applause.)? For transforming how we think about sports.? A dedicated writer and storyteller, Mr. Deford has offered a consistent, compelling voice in print and on radio, reaching beyond scores and statistics to reveal the humanity woven into the games we love.? (Applause.)?
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Joan Didion.? (Applause.)? For her mastery of style in writing.? Exploring the culture around us and exposing the depths of sorrow, Ms. Didion has produced works of startling honesty and fierce intellect, rendered personal stories universal, and illuminated the seemingly peripheral details that are central to our lives.? (Applause.)?
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Robert D. Putnam.? (Applause.)? For deepening our understanding of community in America.? Examining how patterns of engagement divide and unite, Dr. Putnam?s writing and research inspire us to improve institutions that make society worth living in, and his insights challenge us to be better citizens.? (Applause.)?
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Marilynne Robinson.? (Applause.)? For her grace and intelligence in writing.? With moral strength and lyrical clarity, Dr. Robinson?s novels and nonfiction have traced our ethical connections to people in our lives, explored the world we inhabit, and defined universal truths about what it means to be human.? (Applause.)?
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Kay Ryan.? (Applause.)? For her contributions as a poet and educator.? A former Poet Laureate of the United States, her witty and compact verse infused with subtle wordplay, reminds us of the power of language to evoke wisdom from the ordinary.? (Applause.)
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Robert B. Silvers.? (Applause.)? For offering critical perspectives on writing.? As the editor and co-founder of The New York Review of Books, he has invigorated our literature with cultural and political commentary, and elevated the book review to a literary art form.? (Applause.)
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Anna Deavere Smith.? (Applause.)? For her portrayal of authentic American voices.? Through profound performances and plays that blend theater and journalism, she has informed our understanding of social issues and conveyed a range of disparate characters.? (Applause.)
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Camilo Jos? Vergara.? (Applause.)? For his stark visual representation of American cities.? By capturing images of urban settings over time, his sequences reflect the vibrant culture of our changing communities and document the enduring spirit that shines through decay.? (Applause.)
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THE PRESIDENT:? Let?s give our honorees one more big round of applause.? (Applause.)?
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Well, I could not imagine a more deserving group of honorees.? We are thrilled to have them here.?
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Fear not, the party is not over.? (Laughter.)? My understanding is the food here at the White House is not bad.? (Laughter.)? And we may get some nice tunes from our Marine Band -- they can play anything, so feel free to make requests.? (Laughter.)?
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But to all the honorees, thank you, again, for enriching our lives in so many different ways.? We?re going to have an opportunity to see you and your families, and take some pictures with the honorees.? In the meantime, enjoy the reception.? And thank you all.? I hope you?ve enjoyed it.? Thank you.? (Applause.)
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END
2:47 P.M. EDT

Source: http://www.whitehouse.gov/the-press-office/2013/07/10/remarks-president-presentation-2012-medals-arts-and-medals-humanities

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Wednesday, July 10, 2013

Survey Says No To Shower Curtains As House Doctors Home ...

As House Doctors home improvement franchise announces Best Bath as a preferred supplier of shower surrounds and bathtubs Zillow Digs survey shows which bathroom trends are the most popular. This new relationship partners House Doctors network of professional installers with Best Baths complete line of modular and one-piece leak-proof bathing units.

Cincinnati, Ohio (PRWEB) July 09, 2013

As House Doctors home improvement franchise announces Best Bath as a preferred supplier of shower surrounds and bathtubs Zillow Digs survey shows 60% of homeowners are planning home improvement projects this summer with the bathrooms being one of the most popular rooms to update.

According to the recent Zillow Digs survey [Zillow Digs __title__ Zillow Digs Survey] survey the most popular bathroom improvement trend today is open and light bathrooms with glass shower enclosures. Homeowners and designers are saying no more shower curtains but let's use free wall space when we can.

Jim Hunter President of House Doctors said, "Gone are the days of the flowery colorful shower curtains, in are the open bright tiled spaces and glass shower surrounds.Tastes in bathrooms have changed over the years. Today people want bright airy bathrooms with cool glass fronted showers. Shower curtains are definitely not as popular as they were a few years ago. That's why bringing Best Bath on as a preferred vendor will be great for both companies and more importantly for our customers. It gives Best Bath access to our franchise network and our franchisees can now offer our customers some of the most innovative and best constructed bathing solutions on the market today."

Zillow Digs is part of a growing number of online resources that are proving popular with home owners in need of inspiration for that next home improvement project. Zillow Digs now has a database of thousands of photos of remodels many of which have estimates for the costs associated with them. Not only that but Zillow Digs users share ideas and comments on the looks that they like.

Hunter continued, ."The bathroom has always been a popular room to upgrade over the years as tastes change. On line resources like Zillow Digs can now give companies like ours the opportunity to keep up to date with the most popular trends that are happening with homeowners today."

ABOUT HOUSE DOCTORS:
For more than 15 years, House Doctors, a 90-plus-unit professional home improvement service, has brought commercial property owners and homeowners high standards of customer service, reliability, and quality workmanship. Every House Doctors location is independently owned and operated. Today, House Doctors continues to expand throughout the United States by offering franchise opportunities.

For the original version on PRWeb visit: http://www.prweb.com/releases/2013/7/prweb10854028.htm

Source: http://www.virtual-strategy.com/2013/07/09/survey-says-no-shower-curtains-house-doctors-home-improvement-franchise-partners-best-bat

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Updated ASCO Guide on Chemoprevention for Breast Cancer

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Source: www.medscape.com --- Monday, July 08, 2013
The organization has issued an update of its guideline on using drugs to reduce the risk of developing breast Cancer. Medscape Medical News ...

Source: http://www.medscape.com/viewarticle/807489?src=rss

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Tuesday, July 9, 2013

NYC Bucket List Restaurant - Mission Chinese

July 09 2013

I checked another item off the ol? bucket list?.

Mission Chinese is a restaurant that has been raved about to the moon and back in the past year. In fact, Zagat listed it as it?s "2013 Top Ten Hottest?Restaurants in the World".??

Joel and I actually tried to dine here in March. We arrived Friday at 7pm (considered Early Bird Special timing for Manhattan) and expected to put our name on the list, grab a couple drinks at a neighborhood bar, and return around 10pm to eat.

We were wrong.

Not only is there a no reservation policy, but when we arrived at 7pm, 90 minutes after opening, they were already?completely?full for the rest of the evening.

Excuse me?!

Naturally, we left deflated.

Last Friday, knowing the city was a bit deserted due to the holiday weekend, we tried again.

Joel and I arrived at 5:45pm, were quoted an hour wait, and were seated by 7pm.

JACKPOT!

So, was all the hype worth it??

Me thinks not. In fact, I think it?s very OVER hyped?.as do many other Yelp reviewers.?

image

First of all, the interior felt a bit dumpy and at some parts, even dirty (are you stacking dishes on the floor?!). ?The service was rather rough and our waiter seemed constantly annoyed, even when we inquired after our beverages 20 minutes after we ordered them.

With that said, I think it?s all part of their schtick?.

image

Our waiter recommended we order 4 dishes, but we went with six in order to taste test as much as possible.

image

Mapo Tofu - a tofu stew with pork shoulder. This definitely tasted very ?authentic" (whatever that means), and while it was okay, it?s tasted a bit, off. ?Perhaps it was the doubanjiang ingredient? ?Not sure, but we only made our way through half of it.

image

Thrice Cooked Bacon - this was easily our favorite dish. The bacon and rice cake dumplings were the perfect combo, if not a wee bit too spicy.

image

Salt Cod Fried Rice - this was good, but it?s fried rice - how could it not be? Nothing to get too excited about.

image

The Pork Belly didn?t even stand a chance once it arrived. I wasn?t expecting thinly sliced meat and as it was listed under hot dishes, it was quite a surprise when the cold, slimy meat hit my tongue.

image

Spicy Scallop XO Noodles - on the menu, this dish sounded like my dream come true. In reality, both Joel and I took one bite and gave them one bite, looked at each other with disgust, and didn?t touch it again. XO is a common seafood sauce, which I should like, but it tasted more like licorice, which I can?t stomach.

image

Would I return to Mission Chinese?

Absolutely not.

Am I glad I crossed it off my list?

Definitely.

And even if someone told me they have a meh experience there, I think I?d want to try it for myself??

I mean, it?s a top ten restaurant in the world?..according to some.

Source: http://caseyculture.tumblr.com/post/55026456800

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VA - Dreaming About India Indian World Music (2013)[FS,UL,BS]

jul 8 2013

VA - Dreaming About India Indian World Music (2013)[FS,UL,BS]

Categoria: Electronica | Enviado por: obelixyz


Artista: VA
Titulo: VA - Dreaming About India Indian World Music (2013)
Estilo: chill out
Calidad: 320 kbps, 44100 Hz, Stereo
Tama?o: 132 Mb


VA - Dreaming About India Indian World Music (2013)
01 Brass - Indian River
02 Giacomo Bondi - New Delhi
03 Brass - Oriental Meditation
04 Mcgrath James - Indian Princess
05 Oxala? - Frammento D?india 3
06 Entalia - Midnight Mint Tea
07 Aurys - Karma Flowers
08 Mcgrath James - Bali Mystery
09 Oxala? - Calcutta Drum And Bass
10 Luna Lounge - Bengala Mantra
11 Antonio Vernuccio - Viaggio Ad Oriente
12 Brass - Buddha Temple
13 Oxala? - Tour Dell?india
14 Foggia Fabrizio - Bombay Dream



VA - Dreaming About India Indian World Music (2013).rar


VA - Dreaming About India Indian World Music (2013).rar


VA - Dreaming About India Indian World Music (2013).rar


VA - Summertime Beach House Collection (2013)
Namie Amuro - Feel (2013)
VA - This Is Cinema Session 6
VA - Chillout Und Lounge Top Hits (2013)
The Doors - Behind Closed Doors The Rarities (2013)
VA - Brasil House 3000 (Essential Chilled Latin House Grooves) (2013)
VA - Destination Ibiza (2013)
Pet Shop Boys - Electric (2013)
VA - RTL Sommer Hits 2013 (2013) [iTunes edition]
Green Day - Greatest Hits I II (2013)
VA - Summer Dance Party (2013)


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Source: http://www.gratismusica.org/descargar/va-dreaming-about-india-indian-world-music-2013fsulbs/

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Having reached the ripe old internet age of 16, Microsoft is shutting down MSN TV this September.

Having reached the ripe old internet age of 16, Microsoft is shutting down MSN TV this September. At least a handful of people will be upset.

Read more...

    


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/uYmyBlIqzwo/having-reached-the-ripe-old-internet-age-of-16-micros-699098948

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Suspicions confirmed: Brain tumors in children have a common cause

Suspicions confirmed: Brain tumors in children have a common cause [ Back to EurekAlert! ] Public release date: 9-Jul-2013
[ | E-mail | Share Share ]

Contact: Dr. Sibylle Kohlst?dt
s.kohlstaedt@dkfz.de
Helmholtz Association of German Research Centres

Brain cancer is the primary cause of cancer mortality in children. Even in cases when the cancer is cured, young patients suffer from the stress of a treatment that can be harmful to the developing brain. In a search for new target structures that would create more gentle treatments, cancer researchers are systematically analyzing all alterations in the genetic material of these tumors. This is the mission of the PedBrain consortium, which was launched in 2010. Led by Professor Stefan Pfister from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), the PedBrain researchers have now published the results of the first 96 genome analyses of pilocytic astrocytomas.

Pilocytic astrocytomas are the most common childhood brain tumors. These tumors usually grow very slowly. However, they are often difficult to access by surgery and cannot be completely removed, which means that they can recur. The disease may thus become chronic and have debilitating effects for affected children.

In previous work, teams of researchers led by Professor Dr. Stefan Pfister and Dr. David Jones had already discovered characteristic mutations in a major proportion of pilocytic astrocytomas. All of the changes involved a key cellular signaling pathway known as the MAPK signaling cascade. MAPK is an abbreviation for "mitogen-activated protein kinase." This signaling pathway comprises a cascade of phosphate group additions (phosphorylation) from one protein to the next a universal method used by cells to transfer messages to the nucleus. MAPK signaling regulates numerous basic biological processes such as embryonic development and differentiation and the growth and death of cells.

"A couple of years ago, we had already hypothesized that pilocytic astrocytomas generally arise from a defective activation of MAPK signaling," says David Jones, first author of the publication. "However, in about one fifth of the cases we had not initially discovered these mutations. In a whole-genome analysis of 96 tumors we have now discovered activating defects in three other genes involved in the MAPK signaling pathway that have not previously been described in astrocytoma."

"Aside from MAPK mutations, we do not find any other frequent mutations that could promote cancer growth in the tumors. This is a very clear indication that overactive MAPK signals are necessary for a pilocytic astrocytoma to develop," says study director Stefan Pfister. The disease thus is a prototype for rare cancers that are based on defects in a single biological signaling process.

In total, the genomes of pilocytic astrocytomas contain far fewer mutations than are found, for example, in medulloblastomas, a much more malignant pediatric brain tumor. This finding is in accordance with the more benign growth behavior of astrocytomas. The number of mutations increases with the age of the affected individuals.

About one half of pilocytic astrocytomas develop in the cerebellum, the other 50 percent in various other brain regions. Cerebellar astrocytomas are genetically even more homogenous than other cases of the disease: In 48 out of 49 cases that were studied, the researchers found fusions between the BRAF gene, a central component of the MAPK signaling pathway, and various other fusion partners.

"The most important conclusion from our results," says study director Stefan Pfister, "is that targeted agents for all pilocytic astrocytomas are potentially available to block an overactive MAPK signaling cascade at various points. We might thus in the future be able to also help children whose tumors are difficult to access by surgery."

###

International collaboration in tumor genome analysis

The International Cancer Genome Consortium (ICGC), a network of scientists from currently 15 countries, aims to obtain a comprehensive description of genomic and epigenomic changes in all significant types of cancer. Germany takes part with the PedBrain Tumor Project to analyze pediatric brain tumors (medulloblastoma, which in Germany affects approximately 100 children each year; and pilocytic astrocytoma, which is diagnosed in approximately 200 children each year). Within the PedBrain Tumor Project, 300 samples of each tumor type will be analyzed, along with the same number of samples of healthy tissue from the same patients, to identify changes that are cancer-specific.

The PedBrain Tumor network consists of researchers from seven institutes led by project coordinator Peter Lichter of DKFZ. Alongside the DKFZ, participating project partners in Heidelberg are: the National Center for Tumor Diseases (NCT), Heidelberg University and the University Hospital, and the European Molecular Biology Laboratory (EMBL). In addition, scientists from Dsseldorf University Hospital and the Max Planck Institute for Molecular Genetics in Berlin have taken on tasks in the network project.

The German Cancer Aid (Deutsche Krebshilfe) provided funds of eight million Euros for PedBrain Tumor. Since July 1, 2012, the project has received another seven million Euros from the Federal Ministry of Education and Research (BMBF).

David T.W. Jones. Barbara Hutter, Natalie Jger, Andrey Korshunov, Marcel Kool, Hans-Jrg Warnatz, Thomas Zichner, Sally R. Lambert, Marina Ryzhova, Dong Anh Khuong Quang, Adam M. Fontebasso, Adrian M. Sttz, Sonja Hutter, Marc Zuckermann, Dominik Sturm, Jan Gronych, Brbel Lasitschka, Sabine Schmidt, Huriye ?eker-Ci1, Hendrik Witt, Marc Sultan, Meryem Ralser, Paul A. Northcott, Volker Hovestadt, Sebastian Bender, Elke Pfaff, Sebastian Stark, Damien Faury, Jeremy Schwartzentruber, Jacek Majewski, Ursula D. Weber, Marc Zapatka, Benjamin Raeder, Matthias Schlesner, Catherine L. Worth, Cynthia C. Bartholomae, Christof von Kalle, Charles D. Imbusch, Sylwester Radomski, Chris Lawerenz, Peter van Sluis, Jan Koster, Richard Volckmann, Rogier Versteeg, Hans Lehrach, Camelia Monoranu, Beate Winkler, Andreas Unterberg, Christel Herold-Mende, Till Milde, Andreas E. Kulozik, Martin Ebinger, Martin U. Schuhmann, Yoon-Jae Cho, Scott L. Pomeroy, Andreas von Deimling, Olaf Witt, Michael D. Taylor, Stephan Wolf, Matthias A. Karajannis, Charles G. Eberhart, Wolfram Scheurlen, Martin Hasselblatt, Keith L. Ligon, Mark W. Kieran, Jan O. Korbel, Marie-Laure Yaspo, Benedikt Brors, Jrg Felsberg, Guido Reifenberger, V. Peter Collins, Nada Jabado, Roland Eils, Peter Lichter and Stefan M. Pfister on behalf of the ICGC PedBrain Tumor Project: Recurrent alterations in FGFR1 and NTRK2 represent novel therapeutic targets in childhood astrocytoma. Nature Genetics (2013) DOI:10.1038/ng.2682

The German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) with its more than 2,500 employees is the largest biomedical research institute in Germany. At DKFZ, more than 1,000 scientists investigate how cancer develops, identify cancer risk factors and endeavor to find new strategies to prevent people from getting cancer. They develop novel approaches to make tumor diagnosis more precise and treatment of cancer patients more successful. The staff of the Cancer Information Service (KID) offers information about the widespread disease of cancer for patients, their families, and the general public. Jointly with Heidelberg University Hospital, DKFZ has established the National Center for Tumor Diseases (NCT) Heidelberg, where promising approaches from cancer research are translated into the clinic. In the German Consortium for Translational Cancer Research (DKTK), one of six German Centers for Health Research, DKFZ maintains translational centers at seven university partnering sites. Combining excellent university hospitals with high-profile research at a Helmholtz Center is an important contribution to improving the chances of cancer patients. DKFZ is a member of the Helmholtz Association of National Research Centers, with ninety percent of its funding coming from the German Federal Ministry of Education and Research and the remaining ten percent from the State of Baden-Wrttemberg.


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Suspicions confirmed: Brain tumors in children have a common cause [ Back to EurekAlert! ] Public release date: 9-Jul-2013
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Contact: Dr. Sibylle Kohlst?dt
s.kohlstaedt@dkfz.de
Helmholtz Association of German Research Centres

Brain cancer is the primary cause of cancer mortality in children. Even in cases when the cancer is cured, young patients suffer from the stress of a treatment that can be harmful to the developing brain. In a search for new target structures that would create more gentle treatments, cancer researchers are systematically analyzing all alterations in the genetic material of these tumors. This is the mission of the PedBrain consortium, which was launched in 2010. Led by Professor Stefan Pfister from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), the PedBrain researchers have now published the results of the first 96 genome analyses of pilocytic astrocytomas.

Pilocytic astrocytomas are the most common childhood brain tumors. These tumors usually grow very slowly. However, they are often difficult to access by surgery and cannot be completely removed, which means that they can recur. The disease may thus become chronic and have debilitating effects for affected children.

In previous work, teams of researchers led by Professor Dr. Stefan Pfister and Dr. David Jones had already discovered characteristic mutations in a major proportion of pilocytic astrocytomas. All of the changes involved a key cellular signaling pathway known as the MAPK signaling cascade. MAPK is an abbreviation for "mitogen-activated protein kinase." This signaling pathway comprises a cascade of phosphate group additions (phosphorylation) from one protein to the next a universal method used by cells to transfer messages to the nucleus. MAPK signaling regulates numerous basic biological processes such as embryonic development and differentiation and the growth and death of cells.

"A couple of years ago, we had already hypothesized that pilocytic astrocytomas generally arise from a defective activation of MAPK signaling," says David Jones, first author of the publication. "However, in about one fifth of the cases we had not initially discovered these mutations. In a whole-genome analysis of 96 tumors we have now discovered activating defects in three other genes involved in the MAPK signaling pathway that have not previously been described in astrocytoma."

"Aside from MAPK mutations, we do not find any other frequent mutations that could promote cancer growth in the tumors. This is a very clear indication that overactive MAPK signals are necessary for a pilocytic astrocytoma to develop," says study director Stefan Pfister. The disease thus is a prototype for rare cancers that are based on defects in a single biological signaling process.

In total, the genomes of pilocytic astrocytomas contain far fewer mutations than are found, for example, in medulloblastomas, a much more malignant pediatric brain tumor. This finding is in accordance with the more benign growth behavior of astrocytomas. The number of mutations increases with the age of the affected individuals.

About one half of pilocytic astrocytomas develop in the cerebellum, the other 50 percent in various other brain regions. Cerebellar astrocytomas are genetically even more homogenous than other cases of the disease: In 48 out of 49 cases that were studied, the researchers found fusions between the BRAF gene, a central component of the MAPK signaling pathway, and various other fusion partners.

"The most important conclusion from our results," says study director Stefan Pfister, "is that targeted agents for all pilocytic astrocytomas are potentially available to block an overactive MAPK signaling cascade at various points. We might thus in the future be able to also help children whose tumors are difficult to access by surgery."

###

International collaboration in tumor genome analysis

The International Cancer Genome Consortium (ICGC), a network of scientists from currently 15 countries, aims to obtain a comprehensive description of genomic and epigenomic changes in all significant types of cancer. Germany takes part with the PedBrain Tumor Project to analyze pediatric brain tumors (medulloblastoma, which in Germany affects approximately 100 children each year; and pilocytic astrocytoma, which is diagnosed in approximately 200 children each year). Within the PedBrain Tumor Project, 300 samples of each tumor type will be analyzed, along with the same number of samples of healthy tissue from the same patients, to identify changes that are cancer-specific.

The PedBrain Tumor network consists of researchers from seven institutes led by project coordinator Peter Lichter of DKFZ. Alongside the DKFZ, participating project partners in Heidelberg are: the National Center for Tumor Diseases (NCT), Heidelberg University and the University Hospital, and the European Molecular Biology Laboratory (EMBL). In addition, scientists from Dsseldorf University Hospital and the Max Planck Institute for Molecular Genetics in Berlin have taken on tasks in the network project.

The German Cancer Aid (Deutsche Krebshilfe) provided funds of eight million Euros for PedBrain Tumor. Since July 1, 2012, the project has received another seven million Euros from the Federal Ministry of Education and Research (BMBF).

David T.W. Jones. Barbara Hutter, Natalie Jger, Andrey Korshunov, Marcel Kool, Hans-Jrg Warnatz, Thomas Zichner, Sally R. Lambert, Marina Ryzhova, Dong Anh Khuong Quang, Adam M. Fontebasso, Adrian M. Sttz, Sonja Hutter, Marc Zuckermann, Dominik Sturm, Jan Gronych, Brbel Lasitschka, Sabine Schmidt, Huriye ?eker-Ci1, Hendrik Witt, Marc Sultan, Meryem Ralser, Paul A. Northcott, Volker Hovestadt, Sebastian Bender, Elke Pfaff, Sebastian Stark, Damien Faury, Jeremy Schwartzentruber, Jacek Majewski, Ursula D. Weber, Marc Zapatka, Benjamin Raeder, Matthias Schlesner, Catherine L. Worth, Cynthia C. Bartholomae, Christof von Kalle, Charles D. Imbusch, Sylwester Radomski, Chris Lawerenz, Peter van Sluis, Jan Koster, Richard Volckmann, Rogier Versteeg, Hans Lehrach, Camelia Monoranu, Beate Winkler, Andreas Unterberg, Christel Herold-Mende, Till Milde, Andreas E. Kulozik, Martin Ebinger, Martin U. Schuhmann, Yoon-Jae Cho, Scott L. Pomeroy, Andreas von Deimling, Olaf Witt, Michael D. Taylor, Stephan Wolf, Matthias A. Karajannis, Charles G. Eberhart, Wolfram Scheurlen, Martin Hasselblatt, Keith L. Ligon, Mark W. Kieran, Jan O. Korbel, Marie-Laure Yaspo, Benedikt Brors, Jrg Felsberg, Guido Reifenberger, V. Peter Collins, Nada Jabado, Roland Eils, Peter Lichter and Stefan M. Pfister on behalf of the ICGC PedBrain Tumor Project: Recurrent alterations in FGFR1 and NTRK2 represent novel therapeutic targets in childhood astrocytoma. Nature Genetics (2013) DOI:10.1038/ng.2682

The German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) with its more than 2,500 employees is the largest biomedical research institute in Germany. At DKFZ, more than 1,000 scientists investigate how cancer develops, identify cancer risk factors and endeavor to find new strategies to prevent people from getting cancer. They develop novel approaches to make tumor diagnosis more precise and treatment of cancer patients more successful. The staff of the Cancer Information Service (KID) offers information about the widespread disease of cancer for patients, their families, and the general public. Jointly with Heidelberg University Hospital, DKFZ has established the National Center for Tumor Diseases (NCT) Heidelberg, where promising approaches from cancer research are translated into the clinic. In the German Consortium for Translational Cancer Research (DKTK), one of six German Centers for Health Research, DKFZ maintains translational centers at seven university partnering sites. Combining excellent university hospitals with high-profile research at a Helmholtz Center is an important contribution to improving the chances of cancer patients. DKFZ is a member of the Helmholtz Association of National Research Centers, with ninety percent of its funding coming from the German Federal Ministry of Education and Research and the remaining ten percent from the State of Baden-Wrttemberg.


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Source: http://www.eurekalert.org/pub_releases/2013-07/haog-scb070913.php

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Saturday, June 29, 2013

Federer's conqueror loses in 3rd-round letdown

Sergiy Stakhovsky of Ukraine plays a return to Jurgen Melzer of Austria during their Men's second round singles match at the All England Lawn Tennis Championships in Wimbledon, London, Friday, June 28, 2013. (AP Photo/Sang Tan)

Sergiy Stakhovsky of Ukraine plays a return to Jurgen Melzer of Austria during their Men's second round singles match at the All England Lawn Tennis Championships in Wimbledon, London, Friday, June 28, 2013. (AP Photo/Sang Tan)

Andy Murray of Britain returns to Tommy Robredo of Spain during their Men's singles match at the All England Lawn Tennis Championships in Wimbledon, London, Friday, June 28, 2013. (AP Photo/Anja Niedringhaus)

Andy Murray of Britain reacts after defeating Tommy Robredo of Spain during their Men's singles match at the All England Lawn Tennis Championships in Wimbledon, London, Friday, June 28, 2013. (AP Photo/Anja Niedringhaus)

Kaia Kanepi of Estonia reacts as she defeats Angelique Kerber of Germany in a Women's second round singles match at the All England Lawn Tennis Championships in Wimbledon, London, Friday, June 28, 2013. (AP Photo/Alastair Grant)

Angelique Kerber of Germany fails to play a return to Kaia Kanepi of Estonia in their Women's second round singles match at the All England Lawn Tennis Championships in Wimbledon, London, Friday, June 28, 2013. (AP Photo/Sang Tan)

(AP) ? The player who stunned Roger Federer in one of Wimbledon's greatest upsets didn't stick around very long.

Two days after eliminating the seven-time champion on Centre Court, Sergiy Stakhovsky fell to Jurgen Melzer in four sets Friday in the third round at the All England Club.

The 116th-ranked Ukrainian couldn't replicate the serve-and-volley magic that stifled Federer, losing 6-2, 2-6, 7-5, 6-3 to the left-handed Austrian. While Federer struggled with Stakhovsky's serve, Melzer broke him six times.

"I'm just a little disappointed that I got so blinded by the game I produced with Roger that I kept going with the same game I played against Jurgen, which was just not right," Stakhovsky said.

Stakhovsky, who called for the trainer and had his right ankle taped in the first set, kept coming to the net even though Melzer was zeroing in on his serve.

"I think I just played stupid," the Ukrainian said.

Doing everything right so far has been second-seeded Andy Murray, who trounced Tommy Robredo 6-2, 6-4, 7-5 under the Centre Court roof to cruise into the fourth round. The U.S. Open champion hasn't dropped a set this week in his bid to become the first British player to win the men's trophy in 77 years.

"I played my best match of the tournament so far," said Murray, who no longer has Federer or Rafael Nadal in his half of the draw and remains on course to meet No. 1 Novak Djokovic in the final.

Advancing to the third round were fourth-seeded David Ferrer and No. 13 Tommy Haas. No. 15 Nicolas Almagro was knocked out by Poland's Jerzy Janowicz in a third-round match.

Among the women, No. 7 Angelique Kerber was ousted in three sets in second-round play by Estonia's Kaia Kanepi. Kerber became the sixth player among the top-10 seeded women to go out.

With four of the top 10 men also gone after the second round, it equals the worst performance by the top 10 at any Grand Slam in the 45-year history of the Open era.

For the second straight day, play was disrupted by rain and the sliding roof was closed over Centre Court. Four men's singles matches didn't start and were rescheduled for Saturday, while three women's singles matches were suspended by darkness.

Among the uncompleted matches, 2011 champion and eighth-seeded Petra Kvitova was down a break in the third set to Ekaterina Makarova, 3-6, 6-2, 2-1.

In a tournament jolted by a rash of injuries and upsets, the player who caused the biggest surprise of them all came crashing back to earth.

Stakhovsky had snapped Federer's streak of reaching 36 Grand Slam quarterfinals on Wednesday, beating perhaps the game's greatest all-time player on the biggest stage in the sport.

On Friday, he was out on Court 3 and couldn't maintain his level of play against Melzer, a 32-year-old all-court player who has reached at least the fourth round of every Grand Slam.

Still, Stakhovsky will always have that momentous victory to hold onto.

"Nobody is going to take it away from me," he said. "If someone would ask me, 'Would you rather beat Roger and lose in next round?' I would always take it, obviously."

Stakhovsky said he struggled to cope with all the distractions and media interviews that came his way after the Federer match.

"It was quite hard for me because yesterday was a busy day," he said. "Everybody wanted to chat. Everybody wanted a piece. It just takes some time and energy off."

Melzer said he didn't care about the pressures on Stakhovsky and just came into the match ready to beat him with his serve returns.

"You go out there and show him that I'm not Roger Federer and I can return his serve and make him play tough volleys," he said. "That was my goal today."

Murray was dominant in beating the 29th-ranked Robredo. It was Murray's 14th straight match win on grass, a run that goes back to last year's London Olympics, where he beat Federer for the gold medal.

Murray lost serve only once and finished with 40 winners against 14 errors.

"I struck the ball very well from the start of the match," he said. "I had a lot of winners tonight and that was probably the most pleasing part because I did not serve very well on the first couple of matches. I hope I can keep playing better."

Murray will next face either No. 20 Mikhail Youzhny or Viktor Troicki.

In other men's play, Ferrer won an all-Spanish encounter against Roberto Bautista Agut to reach the third round for a sixth consecutive year.

Ferrer advanced with a scrappy 6-3, 3-6, 7-6 (4), 7-5 win in a match originally scheduled for Thursday but pushed back because of rain. He will next face No. 26 Alexandr Dolgopolov.

Melzer will face Janowicz, who served 30 aces and beat Almagro 7-6 (6), 6-3, 6-4 on Centre Court to reach the fourth round at a Grand Slam for the first time.

Only six men and four women ? 10 total ? among the top 10 seeds reached the third round ? tying the performance at Wimbledon in 1996 (four men, six women) and the French Open in 1998 (two men, eight women).

It's the worst performance by the top 10 women's seeds at any Slam in the Open era. The previous low was five at the 2001 French Open.

In another twist, this tournament has produced the fewest five-set matches (12) over the first two rounds at Wimbledon in the Open era. The previous record was 13 in 1981.

Britain's Laura Robson beat 117th-ranked Colombian qualifier Mariana Duque-Marino 6-4, 6-1 under the Centre Court roof to reach Wimbledon's third round for the first time.

Robson, who won the Wimbledon girls' title in 2008, has steadily climbed the rankings and has a good chance of getting into the second week.

"It's a big win for me," Robson said. "Any match on Centre Court is a big one. It was a great atmosphere out there today, and the roof being closed just makes it louder."

Among the early casualties in the men's draw was Grigor Dimitrov, one of the rising stars in tennis. He was eliminated in the second round in a five-set, rain-delayed match that lasted more than four hours over two days.

With girlfriend Maria Sharapova cheering him from the stands on Court 3, the 29th-seeded Bulgarian fell to 55th-ranked Slovenian Grega Zemlja 3-6, 7-6 (4), 3-6, 6-4, 11-9.

Zemlja hit a forehand passing shot on his sixth match point to become the first Slovenian to reach the third round at the All England Club.

Dimitrov is known as "Baby Fed" for a playing style, especially his one-handed backhand in the manner of Roger Federer's. But like Federer, Dimitrov failed to get to Round 3.

"Things happen I guess for a reason," Dimitrov said. "But it's a good learning curve for me. I'm going to step out strong for the upcoming weeks."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-06-28-TEN-Wimbledon/id-be3a063e220748989c010dee37b75723

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Friday, June 28, 2013

NYC Council passes plans for new police oversight

NEW YORK (AP) ? The most expansive plans in years to impose new oversight on the New York Police Department passed the City Council early Thursday, as lawmakers voted to create an outside watchdog and make it easier to bring racial profiling claims against the nation's largest police force.

Both passed with enough votes to override expected vetoes, marking an inflection point in the public debate and power dynamics that have set the balance between prioritizing safety and protecting civil liberties here.

Proponents see the legislation as a check on a police department that has come under scrutiny for its heavy use of a tactic known as stop and frisk and its extensive surveillance of Muslims, as disclosed in a series of stories by The Associated Press.

"New Yorkers know that we can keep our city safe from crime and terrorism without profiling our neighbors," Councilman Brad Lander, who spearheaded the measures with Councilman Jumaane Williams, said at a packed and emotional City Council meeting that began shortly before midnight and stretched into the early morning. In a sign of the national profile the measures has gained, NAACP President Benjamin Jealous was in the audience, while hip hop impresario Russell Simmons tweeted to urge the measures' passage.

Critics say the measures would impinge on techniques that have wrestled crime down dramatically and would leave the NYPD "pointlessly hampered by outside intrusion and recklessly threatened by second-guessing from the courts," in Mayor Michael Bloomberg's words. He vowed in a statement minutes after the vote to veto the measures and continue urging lawmakers to take his side.

But while it's too soon to settle how the initiatives may play out in practice if they survive the expected veto, they already have shaped politics and perception.

Besides giving ground to complaints that the NYPD hasn't been sensitive enough to civil rights and racial fairness, the legislation has put the three-term mayor and his popular police commissioner, Raymond Kelly, in the uncommon position of possibly losing a high-profile fight on public safety. They have gone to lengths to make their criticisms heard, most recently in a Monday news conference at which Bloomberg envisioned gang members lodging discriminatory-policing complaints and Kelly invoked "al-Qaeda wannabes."

Yet on Wednesday, council members rebuffed those concerns and approved the measures by a wide margin.

"It just became so polarized," said Eugene O'Donnell, a John Jay College of Criminal Justice professor who follows issues related to the NYPD. "(The mayor and commissioner) just dug in their heels, for whatever reason, and they ended up with the City Council coalescing around a pretty dramatic set of steps."

The measures follow on decades of efforts to empower outside input on the NYPD, or at least facets of it. Then-Mayor John Lindsay's efforts to establish an independent civilian complaint board in the 1960s spurred a bitter clash with a police union, which said the panel would hinder policing and mobilized a referendum on it. Voters defeated it.

More than two decades later, private citizens were appointed to the Civilian Complaint Review Board, which handles mainly misconduct claims against individual officers. A 1990s police corruption scandal spurred a recommendation for an independent board to investigate corruption; a Commission to Combat Police Corruption was established in 1995, but it lacks subpoena power.

Courts also have exercised some oversight, including through a 1985 federal court settlement that set guidelines for the NYPD's intelligence-gathering. And the City Council has weighed in before, including with a 2004 law that barred racial or religious profiling as "the determinative factor" in police actions, a measure Bloomberg signed.

The new measures are further-reaching than any of that, proponents and critics agree.

One would establish an inspector general with subpoena power to explore and recommend, but not force, changes to the NYPD's policies and practices. Various law enforcement agencies, including the FBI and the Los Angeles Police Department, have inspectors general.

The other would give people more latitude if they felt they were stopped because of bias based on race, sexual orientation or certain other factors.

Plaintiffs wouldn't necessarily have to prove that a police officer intended to discriminate. Instead, they could offer evidence that a practice such as stop and frisk affects some groups disproportionately, though police could counter that the disparity was justified to accomplish a substantial law enforcement end. The suits couldn't seek money, just court orders to change police practices.

The proposals were impelled partly by concern about the roughly 5 million stop and frisks the NYPD has conducted in the last decade, with more than 80 percent of those stopped being black or Hispanic and arrests resulting less than 15 percent of the time. But proponents also point to the department's spying on Muslims, which has included infiltrating Muslim student groups and putting informants in mosques, as the AP series showed.

The poor, mostly Muslim members of a South Asian advocacy group called Desis Rising Up and Moving "feel the impact of both issues ? surveillance, as Muslims ? and stop and frisk," which is prevalent in a Queens neighborhood where many members live, said Fahd Ahmed, the group's legal director.

Stop and frisk is already the subject of a federal lawsuit brought by four men who claim they were stopped solely because of their race, along with hundreds of thousands of others stopped in the last decade. A judge is considering whether to order reforms to the police policy. City attorneys argued the stops were lawful and not based on race alone.

"(The legislation) can have a tangible effect by virtue of the policy work that will come out of an inspector general's office and by virtue of the accountability that will come out of the profiling bill," said proponent Donna Lieberman, the executive director of the New York Civil Liberties Union. "But, also, they will be a statement to the people of New York that we care about fair and just policing."

The NYPD has defended the surveillance and stop and frisks as legal, and critics of the new legislation point to another set of statistics: Killings and other serious offenses have fallen 34 percent since 2001, while the number of city residents in jails and prisons has fallen 31 percent.

"These dangerous pieces of legislation will only hurt our police officers' ability to protect New Yorkers and sustain this tremendous record of accomplishment," Bloomberg said in his statement Thursday.

They could tie the department up in lawsuits and complaints, inject courts and an inspector general into tactical decisions and make "proactive policing by police officers extinct in our city," he said.

If the measures ultimately survive, Bloomberg won't be in City Hall to see much of the outcome. The term-limited mayor leaves office this year.

Democratic mayoral candidates have generally said the practice needs changing. Some Republicans, meanwhile, have embraced the NYPD's view.

___

Follow Jennifer Peltz at http://twitter.com/jennpeltz

Source: http://news.yahoo.com/nyc-council-passes-plans-police-oversight-063043528.html

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Woman indicted in mailing of ricin-laced letters (CNN)

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Obama has short list of potential Bernanke successors: source

By Steve Holland

WASHINGTON (Reuters) - The White House has assembled a short list of candidates to succeed Federal Reserve Chairman Ben Bernanke, a source familiar with the process said on Thursday, and U.S. Treasury Secretary Jack Lew is running the search.

Bernanke is expected to leave when his second term as head of the central bank ends on January 31, after an eventful eight years in helping the U.S. economy recover from the worst recession since the Great Depression.

President Barack Obama hinted in a television interview this month that Bernanke would step down, comparing him to longtime FBI Director Robert Mueller, who agreed to stay two years longer in the job than he had planned, and is now to leave.

Lew has assembled a short list with help from several senior White House officials, the source said, speaking on the condition of anonymity.

There was no information on who is on the list, although Fed Vice Chair Janet Yellen, former Obama adviser Lawrence Summers and former Treasury Secretary Timothy Geithner are considered to be likely leading choices.

"We decline to comment on speculation on any personnel matters until the president has made his decisions and is ready to announce them," said Amy Brundage, a White House spokeswoman.

"The president believes that Chairman Bernanke is a vital and excellent partner in promoting our economic recovery and he continues to serve admirably and with distinction during this important time for our country," she said.

BERNANKE SILENT; YELLEN SEEN IN THE LEAD

Bernanke has yet to say whether he would like to serve another four years at the helm of the central bank, but has done little to dampen speculation he is ready to leave.

The likely succession could come at a delicate juncture for U.S. monetary policy.

Bernanke said last week that the central bank expected to lighten up later this year on the amount of money it is pumping into the economy each month through a bond-buying program.

He said the Fed would likely draw that program to a full close around the middle of next year, when policymakers at the central bank expect the jobless rate will have fallen to around 7 percent from its current 7.6 percent.

Those comments spurred a big selloff in stock markets around the globe and sent the yield on the benchmark 10-year U.S. Treasury note soaring. It reached a 22-month high of 2.67 percent on Monday.

Fed officials have mounted a concerted effort to convince markets they overreacted to the chairman's remarks, and they have underscored the central bank's commitment to keep overnight interest rate near zero until unemployment drops to at least 6.5 percent. Stock markets have since stabilized and bond yields have fallen back.

The market volatility, however, underscored the tricky task the Fed faces in stepping away from the controversial and unprecedented easing of monetary policy Bernanke led.

To combat the deep recession and heal the scars from the financial crisis that followed the bursting of the U.S. housing bubble, the Fed pressed overnight rates to near zero, where they have been since December 2008. It also more than tripled its balance sheet to $3.4 trillion through a series of bond purchases.

The next chairman of the central bank will likely face the task of unwinding that monetary largesse.

In a Reuters poll of economists earlier this month, the vast majority said Obama was likely to tap Yellen to take over.

Yellen, who has served as Fed vice chair since October 2010, is considered a forceful advocate of aggressive action to lift unemployment. If nominated and confirmed by the Senate, she would be the first woman to lead the central bank.

(Reporting by Steve Holland; Writing by Douwe Miedema and Tim Ahmann; Editing by Lisa Shumaker)

Source: http://news.yahoo.com/obama-shortlist-succeed-federal-chairman-bernanke-003944227.html

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Hedge fund alternative investors love ? Bankrate, Inc.

Institutional investors are increasingly turning to mutual funds over hedge funds for strategy diversification. Just over a quarter, 26 percent, of institutions use hedge funds for exposure to long-short strategies this year, compared to 61 percent in 2010, according to a survey released this week by Morningstar and Barron's.

Long-short mutual funds take mostly long positions, buying investments they believe will go up, while hedging their bets with a smaller amount of short positions, or investments they think will go down. There are other types of alternative strategies --?for instance, market neutral strategies that take long and short positions but avoid stocks to lessen volatility. In general, alternative investment strategy funds "provide a smoother ride over time," says Nadia Papagiannis, CFA, director of alternative fund research at Morningstar.

During the events of 2008, institutional investors found themselves stuck in illiquid, highly leveraged hedge funds that only a year or two before had returned outsized returns.

"In 2008, hedge funds delivered high losses. Investors were stuck with illiquid investments they had to pay management fees on but couldn't get out of," says Papagiannis.

Mutual funds offer liquidity and transparency, plus lower fees for similar strategies. "When you are getting double-digit returns, it's?OK to pay 2 percent management fees and a 20 percent performance fee. But with mediocre returns, that eats away at benefits. Plus, if you can find something with lower costs, that is something that as a fiduciary, you have look at," she says.

The average expense ratio of the long/short equity fund category on the Morningstar website is 1.96 percent.

Advisers to small investors are also interested in the risk-management benefits of alternative strategies. For investors, allocating a portion of their portfolio to an alternative strategy fund helps cushion the downside when big stock market drops happen. That downside cushion means less return on the upside as well.

"In order to build wealth over time, you need to have a little bit of a smaller upside and a lot smaller downside. That way, you can build wealth more effectively over time rather than having a couple good up years and then big down years," says Papagiannis.

Investors scared of living through another stock market drop like the one in 2008 and 2009 may want to consider incorporating some strategies that behave differently than the rest of their investments.

Follow me on Twitter: @SheynaSteiner.

***
Senior investing reporter Sheyna Steiner is a co-author of "Future Millionaires' Guidebook," an e-book written by Bankrate editors and reporters. It's available at all the major e-book retailers.

Source: http://www.bankrate.com/financing/investing/hedge-fund-alternative-investors-love/

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Thursday, June 27, 2013

Scientist working to break vicious cycle causing vision loss in diabetes

Scientist working to break vicious cycle causing vision loss in diabetes [ Back to EurekAlert! ] Public release date: 27-Jun-2013
[ | E-mail | Share Share ]

Contact: Toni Baker
tbaker@gru.edu
706-721-4421
Medical College of Georgia at Georgia Regents University

AUGUSTA, Ga. it's a vicious cycle that robs people with diabetes of their vision.

The hallmark high glucose of the disease causes inflammation that produces free radicals that cause inflammation that produces more free radicals, explains Dr. Manuela Bartoli, vision scientist at the Medical College of Georgia at Georgia Regents University.

If that's not bad enough, the body's endogenous system for dealing with free radicals also is dramatically impacted by diabetes, said Bartoli, who recently received a $1.8 million grant from the National Eye Institute to try to bolster that system and interrupt the destructive cycle.

Nearly 10 percent of the U.S. population has diabetes, according to the National Diabetes Foundation, and nearly half those individuals will develop diabetic retinopathy, according to the National Eye Institute.

Culprit free radicals are actually normal byproducts of the body's constant use of oxygen and, despite their derivative status, also are important signaling molecules in the body. Problems result when there are too many, like in diabetes, and their natural tendency to bond starts wreaking havoc on cells and DNA. In fact, excessive levels are thought to be a major contributor to a wide variety of diseases as well as aging.

The thioredoxin system typically works to maintain a healthy level of free radicals by neutralizing excess but, like many body systems, the thioredoxin system slows with age and diabetes hastens the process.

"This increase in free radicals results in an inability to put them to good use," Bartoli said. "Instead, we accumulate the damage they induce." In the case of the eyes and diabetes, over time the overwhelmed system destroys blood vessels that deliver blood and nutrition. In another biological irony, the starving eyes grow new blood vessels but they are fragile, leaky and often misplaced so ultimately they destroy vision.

Bartoli believes a selenium supplement could give the thioredoxin system the shot in the arm needed to stay efficient and effective. Selenium is a byproduct itself, resulting from copper-refining and used to make glass, alloys and more. It is also found in fish, nuts and grains.

Thioredoxin reductase, a protein essential to the recycling of the system, is dependent on selenium and Bartoli has found that protein's activity is reduced in an animal model of diabetic retinopathy and in retinas of human diabetic donors. Bartoli believes the cascade of cellular change resulting from high glucose levels impairs thioredoxin reductase. So she wants to better understand how the system works, exactly what happens to thioredoxin reductase and whether supplements of selenium can help the natural antioxidant system work better in diabetes.

In a related study, funded by the International Retinal Research Foundation, she is looking for an early sign of eye damage and possibly another window of intervention.

Currently, swelling of the macula the central part of the retina responsible for central vision is the first sign of treatable trouble. Anti-inflammatories injected into the eyes can help.

However increased blood levels of uric acid, a part of the inflammatory process that leads to swelling, may be an earlier indicator, Bartoli said. Uric acid is a byproduct of purine metabolism and is typically eliminated in the urine. High uric acid levels are associated with cardiovascular disease and gout as well as diabetes but it hasn't been well studied in the eye.

"We want to validate hyperuricemia as a risk factor for progression of diabetic retinopathy," she said. So she and her colleagues are measuring levels in the blood and eye fluid to see if they correlate with each other and with progressive eye damage. They also are reducing uric acid levels by giving two drugs already on the market, one that blocks formation and another that enhances excretion. Thinking that uric acid levels also may be a biomarker, she eventually wants to see how uric acid levels correlate with disease progression in humans.

"As the ancients said: 'The eyes are the mirror of the soul.' We also know that whatever happens in the eye is an expression of what is happening in the rest of the body," Bartoli said. "We want to better understand the causes of inflammation in the eye in diabetes and find better ways to manage it as well as byproducts such as uric acid. Ultimately, of course, we hope to protect sight."

A National Eye Institute fellowship to GRU Graduate Student Folami Lamoke also is supporting the thioredoxin sudies. Bartoli is a faculty member in the MCG Department of Ophthalmology and the GRU James and Jean Culver Vision Discovery Institute.

###

Media Contact:

Toni Baker
Communications Director
Medical College of Georgia
Georgia Regents University
706-721-4421 Office
706-825-6473 Cell
tbaker@gru.edu


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Scientist working to break vicious cycle causing vision loss in diabetes [ Back to EurekAlert! ] Public release date: 27-Jun-2013
[ | E-mail | Share Share ]

Contact: Toni Baker
tbaker@gru.edu
706-721-4421
Medical College of Georgia at Georgia Regents University

AUGUSTA, Ga. it's a vicious cycle that robs people with diabetes of their vision.

The hallmark high glucose of the disease causes inflammation that produces free radicals that cause inflammation that produces more free radicals, explains Dr. Manuela Bartoli, vision scientist at the Medical College of Georgia at Georgia Regents University.

If that's not bad enough, the body's endogenous system for dealing with free radicals also is dramatically impacted by diabetes, said Bartoli, who recently received a $1.8 million grant from the National Eye Institute to try to bolster that system and interrupt the destructive cycle.

Nearly 10 percent of the U.S. population has diabetes, according to the National Diabetes Foundation, and nearly half those individuals will develop diabetic retinopathy, according to the National Eye Institute.

Culprit free radicals are actually normal byproducts of the body's constant use of oxygen and, despite their derivative status, also are important signaling molecules in the body. Problems result when there are too many, like in diabetes, and their natural tendency to bond starts wreaking havoc on cells and DNA. In fact, excessive levels are thought to be a major contributor to a wide variety of diseases as well as aging.

The thioredoxin system typically works to maintain a healthy level of free radicals by neutralizing excess but, like many body systems, the thioredoxin system slows with age and diabetes hastens the process.

"This increase in free radicals results in an inability to put them to good use," Bartoli said. "Instead, we accumulate the damage they induce." In the case of the eyes and diabetes, over time the overwhelmed system destroys blood vessels that deliver blood and nutrition. In another biological irony, the starving eyes grow new blood vessels but they are fragile, leaky and often misplaced so ultimately they destroy vision.

Bartoli believes a selenium supplement could give the thioredoxin system the shot in the arm needed to stay efficient and effective. Selenium is a byproduct itself, resulting from copper-refining and used to make glass, alloys and more. It is also found in fish, nuts and grains.

Thioredoxin reductase, a protein essential to the recycling of the system, is dependent on selenium and Bartoli has found that protein's activity is reduced in an animal model of diabetic retinopathy and in retinas of human diabetic donors. Bartoli believes the cascade of cellular change resulting from high glucose levels impairs thioredoxin reductase. So she wants to better understand how the system works, exactly what happens to thioredoxin reductase and whether supplements of selenium can help the natural antioxidant system work better in diabetes.

In a related study, funded by the International Retinal Research Foundation, she is looking for an early sign of eye damage and possibly another window of intervention.

Currently, swelling of the macula the central part of the retina responsible for central vision is the first sign of treatable trouble. Anti-inflammatories injected into the eyes can help.

However increased blood levels of uric acid, a part of the inflammatory process that leads to swelling, may be an earlier indicator, Bartoli said. Uric acid is a byproduct of purine metabolism and is typically eliminated in the urine. High uric acid levels are associated with cardiovascular disease and gout as well as diabetes but it hasn't been well studied in the eye.

"We want to validate hyperuricemia as a risk factor for progression of diabetic retinopathy," she said. So she and her colleagues are measuring levels in the blood and eye fluid to see if they correlate with each other and with progressive eye damage. They also are reducing uric acid levels by giving two drugs already on the market, one that blocks formation and another that enhances excretion. Thinking that uric acid levels also may be a biomarker, she eventually wants to see how uric acid levels correlate with disease progression in humans.

"As the ancients said: 'The eyes are the mirror of the soul.' We also know that whatever happens in the eye is an expression of what is happening in the rest of the body," Bartoli said. "We want to better understand the causes of inflammation in the eye in diabetes and find better ways to manage it as well as byproducts such as uric acid. Ultimately, of course, we hope to protect sight."

A National Eye Institute fellowship to GRU Graduate Student Folami Lamoke also is supporting the thioredoxin sudies. Bartoli is a faculty member in the MCG Department of Ophthalmology and the GRU James and Jean Culver Vision Discovery Institute.

###

Media Contact:

Toni Baker
Communications Director
Medical College of Georgia
Georgia Regents University
706-721-4421 Office
706-825-6473 Cell
tbaker@gru.edu


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-06/mcog-swt062713.php

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