Thursday, July 11, 2013

Remarks by the President in Presentation of the 2012 Medals of Arts and the Medals of Humanities

The White House

Office of the Press Secretary

For Immediate Release

July 10, 2013

East Room

2:16 P.M. EDT
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THE PRESIDENT:? Thank you so much.? (Applause.)? Thank you. (Applause.)? Hey!? Thank you.? Everybody, please have a seat.? See, everybody is cheering because I've bought their books, I've seen their movies, I buy their records.? (Laughter.)? So we're major contributors here.
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Well, hello, everybody, and welcome to the White House.? Thank you for joining us to celebrate the recipients of the 2012 -- because I guess this is retrospective -- National Medal of Arts and National Humanities Medals.
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One of the special privileges of this office is getting a chance to honor individuals who?ve played an important role in my life as well as in the nation?s life.? And that?s what today is all about -- celebrating some extraordinary men and women who?ve used their talents in the arts and the humanities to open up minds and nourish souls, and help us understand what it means to be human, and what it means to be an American.
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I want to give some special thanks to the people who help to preserve and to support that cultural legacy -- the Acting Chairwoman of the National Endowment for the Arts, Joan Shigekawa.? Give Joan a big round of applause.? (Applause.)? Where is she?? There she is.? And her predecessor, the irrepressible Rocco Landesman -- (applause) -- as well as the Acting Chairwoman of the National Endowment for the Humanities, Carole Watson.? (Applause.)? Both organizations do an incredible job lifting up some of today?s best artists and scholars, and helping to cultivate the next generation of talent and intellect.
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And I?d like to also acknowledge the co-chairs of the President?s Committee on the Arts and Humanities, George Stevens, Jr. -- where?s George?? There he is.? (Applause.)? As well as Margo Lion -- where?s Margo?? Good to see you.? (Applause.)? As well as members of Congress who are here today, all of whom support the arts.
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But we are primarily here to acknowledge these incredible individuals.? And, frankly, this is just fun for me because I feel like I know you all because I've enjoyed your performances; your writings have fundamentally changed me -- I think for the better, Marilynne.? I believe that.
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At first glance, this is a pretty diverse group.? We?ve got incredible singers and dancers; we have poets and producers; musicians, playwrights, scholars.?? They come from all across the country, all around the world.? And yet, for all their differences, today?s honorees have one thing in common -- and that is they are teachers.? Whether they realize it or not, they?ve taught us about ourselves and about our world.
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American philosopher Will Durant once wrote, ?The aim of art is to represent not the outward appearance of things, but their inward significance.?? And that's an extraordinary skill -- to tell the untold stories of history; to reveal the sculpture that's waiting there in a block of stone; to transform written music into song; to make it look like those planes in space are actually flying like they are.? (Laughter.)? I'm just saying, I remember when I first saw Star Wars.? (Laughter.)? There?s a whole generation that thinks special effects always look like they do today.? (Laughter.)? But it used to be you?d see, like, the string -- (laughter) -- on the little model spaceships.? Anyway, I'm being led astray.? (Laughter.)???
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Because the arts and the humanities aren?t just a source of entertainment, they challenge us to think and to question and to discover, to seek that inward significance -- and that helps us grow and to change and to reach new heights, and to understand each other at a time when the world is constantly crying for the capacity to bridge that gap and speak to people who aren't like us.
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And that?s exactly what these artists and these humanists have done -- by working hard, developing their craft, following their dreams, never giving up.?
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Somebody like Allen Toussaint, who is being honored here for his incredible contributions to the rhythm and blues and jazz music of his beloved New Orleans.? After his hometown was battered by Katrina and Allen was forced to evacuate, he did something even more important for his city -- he went back.? And since then, Allen has devoted his musical talent to lifting up and building up a city.? And today, he?s taking the stage all over the world, with all kinds of incredible talent, doing everything he can to revive the legendary soul of the Big Easy.
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Somebody like Ernest Gaines, who grew up as the descendent of sharecroppers in the South and farming the same land as his ancestors.? He did not let that define his future.? Instead, he took that experience and used it to help fill in gaps in American literature with the stories of African American life.? And then, Ernest moved back to Louisiana, onto the very same land he and his family had once worked.? And he spent more than 20 years teaching college students to find their own voices and reclaiming some of the stories of their own families and their own lives.
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Somebody like Joan Didion, who, rightly, has earned distinction as one of most celebrated American writers of her generation.? I?m surprised she hasn?t already gotten this award. (Laughter.)? But in her early years, she was in school only sporadically, basically taught herself how to read while she and her family followed her Army officer father around the country.? She obviously learned quickly.? She won a contest for Vogue in college; gave up her dream of being an oceanographer, writing became her world.? And today, decades into her career, she remains one of our sharpest and most respected observers of American politics and culture.
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What?s true for those three is true for all the recipients here.? So many of you have touched me and touched Michelle, and now we?re trying to get them to -- Malia and Sasha to see some of Anna?s work, or read ?The Iliad*? because we want to share that, because we think it was important to us.
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And we celebrate people like our honorees here today not just because of their talent, but because they create something new.? They create a new space and that becomes a lasting contribution to American life.? And that?s true for all of these honorees.
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So together, the men and women with us today have helped us appreciate individual talent, but as I said earlier, they?ve also helped us to bridge our differences -- to recognize all the things we share as Americans, whether it?s arts or humanities or sports.?
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Frank, I grew up reading Sports Illustrated, and I think it was very good for me.? I don't know about you.? (Laughter.)? Because all these endeavors, they don't discriminate, they don't prejudge -- they speak to all of us equally if we?re open to it. They?re part of all of our common heritage.? They convey all these distinct voices and emotions and stories, and that's us.? That's who we are.??
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So for more than 200 years that culture has helped shape our views of democracy and freedom and tolerance and progress.? Sometimes the observations or the incredible art or scholarship that?s been done by these honorees are overlooked, but somewhere they?re having an impact.? And like Bobby Kennedy talked about, they create ?ripples of hope.?? They?re like stones in a lake, and it emanates, and we never know exactly how, or who, will be touched by it.? But it makes a difference.? And it?s made us better.?
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And the work that we honor today, the lifetime achievement of these artists and these scholars, reminds us that the human imagination is still the most powerful tool that we have as a people.? That?s why we celebrate their creativity and the fundamental optimism, the notion that if they work that hard somebody will actually pay attention.? That?s why we have to remain committed to the dreamers and the creators and innovators who fuel that progress and help us light the way ahead, because our children, our grandchildren deserve to grow up in a country where their dreams know no bounds and their ambitions extend as far as their talents and hard work can take them.? And it?s important that they have examples -- people who?ve carved out a path for them.?
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So I want to thank today?s honorees for doing their part to foster that spirit, to enrich our entire nation.? Every one of them has helped us see beyond outward appearances and appreciate the significance of what?s within.? And for that we are incredibly grateful.
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So it is now my privilege to present these medals to each of them as one of our military aides reads their citations.? (Applause.)
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(The citations are read and the medals are awarded.)
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MILITARY AIDE:? National Medal of Arts recipients:?
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Herb Alpert.? (Applause.)? For his varied contributions to music and the fine arts.? The musician behind Tijuana Brass phenomenon and co-founder of A&M Records, which launched several storied careers, Mr. Alpert is also a philanthropist who shares the power of arts education with young people across our country. (Applause.)
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Lin Arison.? (Applause.)? For her contributions as a philanthropist and arts education advocate.? Co-founder of the National YoungArts Foundation and the New World Symphony, Ms. Arison?s work celebrates, showcases, and supports the next generation of great American artists.? (Applause.)
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Joan Myers Brown.? (Applause.)? For her contributions as a dancer, choreographer and artistic director.? Founder of the Philadelphia Dance Company, Ms. Brown carved out an artistic haven for African American dancers and choreographers to innovate, create, and share their unique visions with the national and global dance communities.? (Applause.)
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Ren?e Fleming.? (Applause.)? For her contributions to American music.? Known to many as ?the people?s diva,? Ms. Fleming has captivated audiences around the world with an adventurous repertoire spanning opera and the classical tradition to jazz and contemporary pop.? (Applause.)
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Ernest J. Gaines.? (Applause.)? For his contributions as an author and teacher.? Drawing deeply from his childhood in the rural South, his works have shed new light on the African American experience and given voice to those who have endured injustice.? (Applause.)
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Ellsworth Kelly.? (Applause.)? For his contributions as a painter, sculptor and printmaker.? A careful observer of form, color and the natural world, Mr. Kelly has shaped more than half a century of abstraction and remains a vital influence in American art.? (Applause.)
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Tony Kushner.? (Applause.)? For his contributions to American theater and film.? Whether for the stage or the silver screen, his scripts have moved audiences worldwide, marrying humor to fury, history to fantasy, and the philosophical to the personal.? (Applause.)
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George Lucas.? (Applause.)? For his contributions to American cinema.? By combining the art of storytelling with boundless imagination and cutting-edge techniques, Mr. Lucas has transported us to new worlds and created some of the most beloved and iconic films of all time.? (Applause.)
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Elaine May.? (Applause.)? For her contributions to American comedy.? With groundbreaking wit and a keen understanding of how humor can illuminate our lives, Ms. May has evoked untold joy, challenged expectations, and elevated spirits across our nation. (Applause.)
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Laurie Olin.? (Applause.)? For his contributions as a preeminent landscape architect.? Renowned for his acute sense of harmony and balance between nature and design, Mr. Olin has dedicated his energy to shaping many iconic spaces around the world and to educating new leaders in his art.? (Applause.)
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Allen Toussaint.? (Applause.)? For his contributions as a composer, producer and performer.? Born and raised in New Orleans, Mr. Toussaint has built a legendary career alongside America?s finest musicians, sustaining his city?s rich tradition of rhythm and blues, and lifting it to the national stage.? (Applause.)
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Accepting on behalf of Washington Performing Arts Society, Jenny Bellfield.? (Applause.)? For bringing world-class performances to our Nation?s Capital.? From concert hall premieres to in-school workshops, Washington Performing Arts Society has drawn renowned artists to the Washington community and inspired generations of young performers to follow their passions.? (Applause.)
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National Humanities Medal recipients:
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Edward L. Ayers.? (Applause.)? For his commitment to making our history as widely available and accessible as possible.? Dr. Ayers?s innovations in digital humanities extend higher learning beyond campus boundaries and allow broad audiences to discover the past in new ways.? (Applause.)
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Accepting on behalf of William G. Bowen, David Bowen.? (Applause.)? For his contributions to the study of economics and his probing research on higher education in America.? While his widely discussed publications have scrutinized the effects of policy, Dr. Bowen has used his leadership to put theories into practice and strive for new heights of academic excellence.
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Jill Ker Conway.? (Applause.)? For her contributions as a historian and trailblazing academic leader.? Dr. Conway has inspired generations of scholars, and her studies of exceptional and empowered women have revealed a common drive that unites women across the globe to create, to lead, and to excel.? (Applause.)
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Natalie Zemon Davis.? (Applause.)? For her insights into the study of history and her exacting eloquence in bringing the past into focus.? With vivid description and exhaustive research, her works allow us to experience life through our ancestors? eyes and to engage truly with our history.? (Applause.)
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Frank Deford.? (Applause.)? For transforming how we think about sports.? A dedicated writer and storyteller, Mr. Deford has offered a consistent, compelling voice in print and on radio, reaching beyond scores and statistics to reveal the humanity woven into the games we love.? (Applause.)?
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Joan Didion.? (Applause.)? For her mastery of style in writing.? Exploring the culture around us and exposing the depths of sorrow, Ms. Didion has produced works of startling honesty and fierce intellect, rendered personal stories universal, and illuminated the seemingly peripheral details that are central to our lives.? (Applause.)?
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Robert D. Putnam.? (Applause.)? For deepening our understanding of community in America.? Examining how patterns of engagement divide and unite, Dr. Putnam?s writing and research inspire us to improve institutions that make society worth living in, and his insights challenge us to be better citizens.? (Applause.)?
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Marilynne Robinson.? (Applause.)? For her grace and intelligence in writing.? With moral strength and lyrical clarity, Dr. Robinson?s novels and nonfiction have traced our ethical connections to people in our lives, explored the world we inhabit, and defined universal truths about what it means to be human.? (Applause.)?
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Kay Ryan.? (Applause.)? For her contributions as a poet and educator.? A former Poet Laureate of the United States, her witty and compact verse infused with subtle wordplay, reminds us of the power of language to evoke wisdom from the ordinary.? (Applause.)
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Robert B. Silvers.? (Applause.)? For offering critical perspectives on writing.? As the editor and co-founder of The New York Review of Books, he has invigorated our literature with cultural and political commentary, and elevated the book review to a literary art form.? (Applause.)
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Anna Deavere Smith.? (Applause.)? For her portrayal of authentic American voices.? Through profound performances and plays that blend theater and journalism, she has informed our understanding of social issues and conveyed a range of disparate characters.? (Applause.)
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Camilo Jos? Vergara.? (Applause.)? For his stark visual representation of American cities.? By capturing images of urban settings over time, his sequences reflect the vibrant culture of our changing communities and document the enduring spirit that shines through decay.? (Applause.)
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THE PRESIDENT:? Let?s give our honorees one more big round of applause.? (Applause.)?
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Well, I could not imagine a more deserving group of honorees.? We are thrilled to have them here.?
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Fear not, the party is not over.? (Laughter.)? My understanding is the food here at the White House is not bad.? (Laughter.)? And we may get some nice tunes from our Marine Band -- they can play anything, so feel free to make requests.? (Laughter.)?
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But to all the honorees, thank you, again, for enriching our lives in so many different ways.? We?re going to have an opportunity to see you and your families, and take some pictures with the honorees.? In the meantime, enjoy the reception.? And thank you all.? I hope you?ve enjoyed it.? Thank you.? (Applause.)
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END
2:47 P.M. EDT

Source: http://www.whitehouse.gov/the-press-office/2013/07/10/remarks-president-presentation-2012-medals-arts-and-medals-humanities

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Wednesday, July 10, 2013

Survey Says No To Shower Curtains As House Doctors Home ...

As House Doctors home improvement franchise announces Best Bath as a preferred supplier of shower surrounds and bathtubs Zillow Digs survey shows which bathroom trends are the most popular. This new relationship partners House Doctors network of professional installers with Best Baths complete line of modular and one-piece leak-proof bathing units.

Cincinnati, Ohio (PRWEB) July 09, 2013

As House Doctors home improvement franchise announces Best Bath as a preferred supplier of shower surrounds and bathtubs Zillow Digs survey shows 60% of homeowners are planning home improvement projects this summer with the bathrooms being one of the most popular rooms to update.

According to the recent Zillow Digs survey [Zillow Digs __title__ Zillow Digs Survey] survey the most popular bathroom improvement trend today is open and light bathrooms with glass shower enclosures. Homeowners and designers are saying no more shower curtains but let's use free wall space when we can.

Jim Hunter President of House Doctors said, "Gone are the days of the flowery colorful shower curtains, in are the open bright tiled spaces and glass shower surrounds.Tastes in bathrooms have changed over the years. Today people want bright airy bathrooms with cool glass fronted showers. Shower curtains are definitely not as popular as they were a few years ago. That's why bringing Best Bath on as a preferred vendor will be great for both companies and more importantly for our customers. It gives Best Bath access to our franchise network and our franchisees can now offer our customers some of the most innovative and best constructed bathing solutions on the market today."

Zillow Digs is part of a growing number of online resources that are proving popular with home owners in need of inspiration for that next home improvement project. Zillow Digs now has a database of thousands of photos of remodels many of which have estimates for the costs associated with them. Not only that but Zillow Digs users share ideas and comments on the looks that they like.

Hunter continued, ."The bathroom has always been a popular room to upgrade over the years as tastes change. On line resources like Zillow Digs can now give companies like ours the opportunity to keep up to date with the most popular trends that are happening with homeowners today."

ABOUT HOUSE DOCTORS:
For more than 15 years, House Doctors, a 90-plus-unit professional home improvement service, has brought commercial property owners and homeowners high standards of customer service, reliability, and quality workmanship. Every House Doctors location is independently owned and operated. Today, House Doctors continues to expand throughout the United States by offering franchise opportunities.

For the original version on PRWeb visit: http://www.prweb.com/releases/2013/7/prweb10854028.htm

Source: http://www.virtual-strategy.com/2013/07/09/survey-says-no-shower-curtains-house-doctors-home-improvement-franchise-partners-best-bat

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Updated ASCO Guide on Chemoprevention for Breast Cancer

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Source: www.medscape.com --- Monday, July 08, 2013
The organization has issued an update of its guideline on using drugs to reduce the risk of developing breast Cancer. Medscape Medical News ...

Source: http://www.medscape.com/viewarticle/807489?src=rss

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Tuesday, July 9, 2013

NYC Bucket List Restaurant - Mission Chinese

July 09 2013

I checked another item off the ol? bucket list?.

Mission Chinese is a restaurant that has been raved about to the moon and back in the past year. In fact, Zagat listed it as it?s "2013 Top Ten Hottest?Restaurants in the World".??

Joel and I actually tried to dine here in March. We arrived Friday at 7pm (considered Early Bird Special timing for Manhattan) and expected to put our name on the list, grab a couple drinks at a neighborhood bar, and return around 10pm to eat.

We were wrong.

Not only is there a no reservation policy, but when we arrived at 7pm, 90 minutes after opening, they were already?completely?full for the rest of the evening.

Excuse me?!

Naturally, we left deflated.

Last Friday, knowing the city was a bit deserted due to the holiday weekend, we tried again.

Joel and I arrived at 5:45pm, were quoted an hour wait, and were seated by 7pm.

JACKPOT!

So, was all the hype worth it??

Me thinks not. In fact, I think it?s very OVER hyped?.as do many other Yelp reviewers.?

image

First of all, the interior felt a bit dumpy and at some parts, even dirty (are you stacking dishes on the floor?!). ?The service was rather rough and our waiter seemed constantly annoyed, even when we inquired after our beverages 20 minutes after we ordered them.

With that said, I think it?s all part of their schtick?.

image

Our waiter recommended we order 4 dishes, but we went with six in order to taste test as much as possible.

image

Mapo Tofu - a tofu stew with pork shoulder. This definitely tasted very ?authentic" (whatever that means), and while it was okay, it?s tasted a bit, off. ?Perhaps it was the doubanjiang ingredient? ?Not sure, but we only made our way through half of it.

image

Thrice Cooked Bacon - this was easily our favorite dish. The bacon and rice cake dumplings were the perfect combo, if not a wee bit too spicy.

image

Salt Cod Fried Rice - this was good, but it?s fried rice - how could it not be? Nothing to get too excited about.

image

The Pork Belly didn?t even stand a chance once it arrived. I wasn?t expecting thinly sliced meat and as it was listed under hot dishes, it was quite a surprise when the cold, slimy meat hit my tongue.

image

Spicy Scallop XO Noodles - on the menu, this dish sounded like my dream come true. In reality, both Joel and I took one bite and gave them one bite, looked at each other with disgust, and didn?t touch it again. XO is a common seafood sauce, which I should like, but it tasted more like licorice, which I can?t stomach.

image

Would I return to Mission Chinese?

Absolutely not.

Am I glad I crossed it off my list?

Definitely.

And even if someone told me they have a meh experience there, I think I?d want to try it for myself??

I mean, it?s a top ten restaurant in the world?..according to some.

Source: http://caseyculture.tumblr.com/post/55026456800

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VA - Dreaming About India Indian World Music (2013)[FS,UL,BS]

jul 8 2013

VA - Dreaming About India Indian World Music (2013)[FS,UL,BS]

Categoria: Electronica | Enviado por: obelixyz


Artista: VA
Titulo: VA - Dreaming About India Indian World Music (2013)
Estilo: chill out
Calidad: 320 kbps, 44100 Hz, Stereo
Tama?o: 132 Mb


VA - Dreaming About India Indian World Music (2013)
01 Brass - Indian River
02 Giacomo Bondi - New Delhi
03 Brass - Oriental Meditation
04 Mcgrath James - Indian Princess
05 Oxala? - Frammento D?india 3
06 Entalia - Midnight Mint Tea
07 Aurys - Karma Flowers
08 Mcgrath James - Bali Mystery
09 Oxala? - Calcutta Drum And Bass
10 Luna Lounge - Bengala Mantra
11 Antonio Vernuccio - Viaggio Ad Oriente
12 Brass - Buddha Temple
13 Oxala? - Tour Dell?india
14 Foggia Fabrizio - Bombay Dream



VA - Dreaming About India Indian World Music (2013).rar


VA - Dreaming About India Indian World Music (2013).rar


VA - Dreaming About India Indian World Music (2013).rar


VA - Summertime Beach House Collection (2013)
Namie Amuro - Feel (2013)
VA - This Is Cinema Session 6
VA - Chillout Und Lounge Top Hits (2013)
The Doors - Behind Closed Doors The Rarities (2013)
VA - Brasil House 3000 (Essential Chilled Latin House Grooves) (2013)
VA - Destination Ibiza (2013)
Pet Shop Boys - Electric (2013)
VA - RTL Sommer Hits 2013 (2013) [iTunes edition]
Green Day - Greatest Hits I II (2013)
VA - Summer Dance Party (2013)


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Source: http://www.gratismusica.org/descargar/va-dreaming-about-india-indian-world-music-2013fsulbs/

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Having reached the ripe old internet age of 16, Microsoft is shutting down MSN TV this September.

Having reached the ripe old internet age of 16, Microsoft is shutting down MSN TV this September. At least a handful of people will be upset.

Read more...

    


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/uYmyBlIqzwo/having-reached-the-ripe-old-internet-age-of-16-micros-699098948

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Suspicions confirmed: Brain tumors in children have a common cause

Suspicions confirmed: Brain tumors in children have a common cause [ Back to EurekAlert! ] Public release date: 9-Jul-2013
[ | E-mail | Share Share ]

Contact: Dr. Sibylle Kohlst?dt
s.kohlstaedt@dkfz.de
Helmholtz Association of German Research Centres

Brain cancer is the primary cause of cancer mortality in children. Even in cases when the cancer is cured, young patients suffer from the stress of a treatment that can be harmful to the developing brain. In a search for new target structures that would create more gentle treatments, cancer researchers are systematically analyzing all alterations in the genetic material of these tumors. This is the mission of the PedBrain consortium, which was launched in 2010. Led by Professor Stefan Pfister from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), the PedBrain researchers have now published the results of the first 96 genome analyses of pilocytic astrocytomas.

Pilocytic astrocytomas are the most common childhood brain tumors. These tumors usually grow very slowly. However, they are often difficult to access by surgery and cannot be completely removed, which means that they can recur. The disease may thus become chronic and have debilitating effects for affected children.

In previous work, teams of researchers led by Professor Dr. Stefan Pfister and Dr. David Jones had already discovered characteristic mutations in a major proportion of pilocytic astrocytomas. All of the changes involved a key cellular signaling pathway known as the MAPK signaling cascade. MAPK is an abbreviation for "mitogen-activated protein kinase." This signaling pathway comprises a cascade of phosphate group additions (phosphorylation) from one protein to the next a universal method used by cells to transfer messages to the nucleus. MAPK signaling regulates numerous basic biological processes such as embryonic development and differentiation and the growth and death of cells.

"A couple of years ago, we had already hypothesized that pilocytic astrocytomas generally arise from a defective activation of MAPK signaling," says David Jones, first author of the publication. "However, in about one fifth of the cases we had not initially discovered these mutations. In a whole-genome analysis of 96 tumors we have now discovered activating defects in three other genes involved in the MAPK signaling pathway that have not previously been described in astrocytoma."

"Aside from MAPK mutations, we do not find any other frequent mutations that could promote cancer growth in the tumors. This is a very clear indication that overactive MAPK signals are necessary for a pilocytic astrocytoma to develop," says study director Stefan Pfister. The disease thus is a prototype for rare cancers that are based on defects in a single biological signaling process.

In total, the genomes of pilocytic astrocytomas contain far fewer mutations than are found, for example, in medulloblastomas, a much more malignant pediatric brain tumor. This finding is in accordance with the more benign growth behavior of astrocytomas. The number of mutations increases with the age of the affected individuals.

About one half of pilocytic astrocytomas develop in the cerebellum, the other 50 percent in various other brain regions. Cerebellar astrocytomas are genetically even more homogenous than other cases of the disease: In 48 out of 49 cases that were studied, the researchers found fusions between the BRAF gene, a central component of the MAPK signaling pathway, and various other fusion partners.

"The most important conclusion from our results," says study director Stefan Pfister, "is that targeted agents for all pilocytic astrocytomas are potentially available to block an overactive MAPK signaling cascade at various points. We might thus in the future be able to also help children whose tumors are difficult to access by surgery."

###

International collaboration in tumor genome analysis

The International Cancer Genome Consortium (ICGC), a network of scientists from currently 15 countries, aims to obtain a comprehensive description of genomic and epigenomic changes in all significant types of cancer. Germany takes part with the PedBrain Tumor Project to analyze pediatric brain tumors (medulloblastoma, which in Germany affects approximately 100 children each year; and pilocytic astrocytoma, which is diagnosed in approximately 200 children each year). Within the PedBrain Tumor Project, 300 samples of each tumor type will be analyzed, along with the same number of samples of healthy tissue from the same patients, to identify changes that are cancer-specific.

The PedBrain Tumor network consists of researchers from seven institutes led by project coordinator Peter Lichter of DKFZ. Alongside the DKFZ, participating project partners in Heidelberg are: the National Center for Tumor Diseases (NCT), Heidelberg University and the University Hospital, and the European Molecular Biology Laboratory (EMBL). In addition, scientists from Dsseldorf University Hospital and the Max Planck Institute for Molecular Genetics in Berlin have taken on tasks in the network project.

The German Cancer Aid (Deutsche Krebshilfe) provided funds of eight million Euros for PedBrain Tumor. Since July 1, 2012, the project has received another seven million Euros from the Federal Ministry of Education and Research (BMBF).

David T.W. Jones. Barbara Hutter, Natalie Jger, Andrey Korshunov, Marcel Kool, Hans-Jrg Warnatz, Thomas Zichner, Sally R. Lambert, Marina Ryzhova, Dong Anh Khuong Quang, Adam M. Fontebasso, Adrian M. Sttz, Sonja Hutter, Marc Zuckermann, Dominik Sturm, Jan Gronych, Brbel Lasitschka, Sabine Schmidt, Huriye ?eker-Ci1, Hendrik Witt, Marc Sultan, Meryem Ralser, Paul A. Northcott, Volker Hovestadt, Sebastian Bender, Elke Pfaff, Sebastian Stark, Damien Faury, Jeremy Schwartzentruber, Jacek Majewski, Ursula D. Weber, Marc Zapatka, Benjamin Raeder, Matthias Schlesner, Catherine L. Worth, Cynthia C. Bartholomae, Christof von Kalle, Charles D. Imbusch, Sylwester Radomski, Chris Lawerenz, Peter van Sluis, Jan Koster, Richard Volckmann, Rogier Versteeg, Hans Lehrach, Camelia Monoranu, Beate Winkler, Andreas Unterberg, Christel Herold-Mende, Till Milde, Andreas E. Kulozik, Martin Ebinger, Martin U. Schuhmann, Yoon-Jae Cho, Scott L. Pomeroy, Andreas von Deimling, Olaf Witt, Michael D. Taylor, Stephan Wolf, Matthias A. Karajannis, Charles G. Eberhart, Wolfram Scheurlen, Martin Hasselblatt, Keith L. Ligon, Mark W. Kieran, Jan O. Korbel, Marie-Laure Yaspo, Benedikt Brors, Jrg Felsberg, Guido Reifenberger, V. Peter Collins, Nada Jabado, Roland Eils, Peter Lichter and Stefan M. Pfister on behalf of the ICGC PedBrain Tumor Project: Recurrent alterations in FGFR1 and NTRK2 represent novel therapeutic targets in childhood astrocytoma. Nature Genetics (2013) DOI:10.1038/ng.2682

The German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) with its more than 2,500 employees is the largest biomedical research institute in Germany. At DKFZ, more than 1,000 scientists investigate how cancer develops, identify cancer risk factors and endeavor to find new strategies to prevent people from getting cancer. They develop novel approaches to make tumor diagnosis more precise and treatment of cancer patients more successful. The staff of the Cancer Information Service (KID) offers information about the widespread disease of cancer for patients, their families, and the general public. Jointly with Heidelberg University Hospital, DKFZ has established the National Center for Tumor Diseases (NCT) Heidelberg, where promising approaches from cancer research are translated into the clinic. In the German Consortium for Translational Cancer Research (DKTK), one of six German Centers for Health Research, DKFZ maintains translational centers at seven university partnering sites. Combining excellent university hospitals with high-profile research at a Helmholtz Center is an important contribution to improving the chances of cancer patients. DKFZ is a member of the Helmholtz Association of National Research Centers, with ninety percent of its funding coming from the German Federal Ministry of Education and Research and the remaining ten percent from the State of Baden-Wrttemberg.


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Suspicions confirmed: Brain tumors in children have a common cause [ Back to EurekAlert! ] Public release date: 9-Jul-2013
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Contact: Dr. Sibylle Kohlst?dt
s.kohlstaedt@dkfz.de
Helmholtz Association of German Research Centres

Brain cancer is the primary cause of cancer mortality in children. Even in cases when the cancer is cured, young patients suffer from the stress of a treatment that can be harmful to the developing brain. In a search for new target structures that would create more gentle treatments, cancer researchers are systematically analyzing all alterations in the genetic material of these tumors. This is the mission of the PedBrain consortium, which was launched in 2010. Led by Professor Stefan Pfister from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), the PedBrain researchers have now published the results of the first 96 genome analyses of pilocytic astrocytomas.

Pilocytic astrocytomas are the most common childhood brain tumors. These tumors usually grow very slowly. However, they are often difficult to access by surgery and cannot be completely removed, which means that they can recur. The disease may thus become chronic and have debilitating effects for affected children.

In previous work, teams of researchers led by Professor Dr. Stefan Pfister and Dr. David Jones had already discovered characteristic mutations in a major proportion of pilocytic astrocytomas. All of the changes involved a key cellular signaling pathway known as the MAPK signaling cascade. MAPK is an abbreviation for "mitogen-activated protein kinase." This signaling pathway comprises a cascade of phosphate group additions (phosphorylation) from one protein to the next a universal method used by cells to transfer messages to the nucleus. MAPK signaling regulates numerous basic biological processes such as embryonic development and differentiation and the growth and death of cells.

"A couple of years ago, we had already hypothesized that pilocytic astrocytomas generally arise from a defective activation of MAPK signaling," says David Jones, first author of the publication. "However, in about one fifth of the cases we had not initially discovered these mutations. In a whole-genome analysis of 96 tumors we have now discovered activating defects in three other genes involved in the MAPK signaling pathway that have not previously been described in astrocytoma."

"Aside from MAPK mutations, we do not find any other frequent mutations that could promote cancer growth in the tumors. This is a very clear indication that overactive MAPK signals are necessary for a pilocytic astrocytoma to develop," says study director Stefan Pfister. The disease thus is a prototype for rare cancers that are based on defects in a single biological signaling process.

In total, the genomes of pilocytic astrocytomas contain far fewer mutations than are found, for example, in medulloblastomas, a much more malignant pediatric brain tumor. This finding is in accordance with the more benign growth behavior of astrocytomas. The number of mutations increases with the age of the affected individuals.

About one half of pilocytic astrocytomas develop in the cerebellum, the other 50 percent in various other brain regions. Cerebellar astrocytomas are genetically even more homogenous than other cases of the disease: In 48 out of 49 cases that were studied, the researchers found fusions between the BRAF gene, a central component of the MAPK signaling pathway, and various other fusion partners.

"The most important conclusion from our results," says study director Stefan Pfister, "is that targeted agents for all pilocytic astrocytomas are potentially available to block an overactive MAPK signaling cascade at various points. We might thus in the future be able to also help children whose tumors are difficult to access by surgery."

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International collaboration in tumor genome analysis

The International Cancer Genome Consortium (ICGC), a network of scientists from currently 15 countries, aims to obtain a comprehensive description of genomic and epigenomic changes in all significant types of cancer. Germany takes part with the PedBrain Tumor Project to analyze pediatric brain tumors (medulloblastoma, which in Germany affects approximately 100 children each year; and pilocytic astrocytoma, which is diagnosed in approximately 200 children each year). Within the PedBrain Tumor Project, 300 samples of each tumor type will be analyzed, along with the same number of samples of healthy tissue from the same patients, to identify changes that are cancer-specific.

The PedBrain Tumor network consists of researchers from seven institutes led by project coordinator Peter Lichter of DKFZ. Alongside the DKFZ, participating project partners in Heidelberg are: the National Center for Tumor Diseases (NCT), Heidelberg University and the University Hospital, and the European Molecular Biology Laboratory (EMBL). In addition, scientists from Dsseldorf University Hospital and the Max Planck Institute for Molecular Genetics in Berlin have taken on tasks in the network project.

The German Cancer Aid (Deutsche Krebshilfe) provided funds of eight million Euros for PedBrain Tumor. Since July 1, 2012, the project has received another seven million Euros from the Federal Ministry of Education and Research (BMBF).

David T.W. Jones. Barbara Hutter, Natalie Jger, Andrey Korshunov, Marcel Kool, Hans-Jrg Warnatz, Thomas Zichner, Sally R. Lambert, Marina Ryzhova, Dong Anh Khuong Quang, Adam M. Fontebasso, Adrian M. Sttz, Sonja Hutter, Marc Zuckermann, Dominik Sturm, Jan Gronych, Brbel Lasitschka, Sabine Schmidt, Huriye ?eker-Ci1, Hendrik Witt, Marc Sultan, Meryem Ralser, Paul A. Northcott, Volker Hovestadt, Sebastian Bender, Elke Pfaff, Sebastian Stark, Damien Faury, Jeremy Schwartzentruber, Jacek Majewski, Ursula D. Weber, Marc Zapatka, Benjamin Raeder, Matthias Schlesner, Catherine L. Worth, Cynthia C. Bartholomae, Christof von Kalle, Charles D. Imbusch, Sylwester Radomski, Chris Lawerenz, Peter van Sluis, Jan Koster, Richard Volckmann, Rogier Versteeg, Hans Lehrach, Camelia Monoranu, Beate Winkler, Andreas Unterberg, Christel Herold-Mende, Till Milde, Andreas E. Kulozik, Martin Ebinger, Martin U. Schuhmann, Yoon-Jae Cho, Scott L. Pomeroy, Andreas von Deimling, Olaf Witt, Michael D. Taylor, Stephan Wolf, Matthias A. Karajannis, Charles G. Eberhart, Wolfram Scheurlen, Martin Hasselblatt, Keith L. Ligon, Mark W. Kieran, Jan O. Korbel, Marie-Laure Yaspo, Benedikt Brors, Jrg Felsberg, Guido Reifenberger, V. Peter Collins, Nada Jabado, Roland Eils, Peter Lichter and Stefan M. Pfister on behalf of the ICGC PedBrain Tumor Project: Recurrent alterations in FGFR1 and NTRK2 represent novel therapeutic targets in childhood astrocytoma. Nature Genetics (2013) DOI:10.1038/ng.2682

The German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) with its more than 2,500 employees is the largest biomedical research institute in Germany. At DKFZ, more than 1,000 scientists investigate how cancer develops, identify cancer risk factors and endeavor to find new strategies to prevent people from getting cancer. They develop novel approaches to make tumor diagnosis more precise and treatment of cancer patients more successful. The staff of the Cancer Information Service (KID) offers information about the widespread disease of cancer for patients, their families, and the general public. Jointly with Heidelberg University Hospital, DKFZ has established the National Center for Tumor Diseases (NCT) Heidelberg, where promising approaches from cancer research are translated into the clinic. In the German Consortium for Translational Cancer Research (DKTK), one of six German Centers for Health Research, DKFZ maintains translational centers at seven university partnering sites. Combining excellent university hospitals with high-profile research at a Helmholtz Center is an important contribution to improving the chances of cancer patients. DKFZ is a member of the Helmholtz Association of National Research Centers, with ninety percent of its funding coming from the German Federal Ministry of Education and Research and the remaining ten percent from the State of Baden-Wrttemberg.


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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-07/haog-scb070913.php

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